Search results for "DNA sequence analyses"

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First Nationwide Molecular Screening Program in Spain for Patients With Advanced Breast Cancer: Results From the AGATA SOLTI-1301 Study

2021

Anàlisi de seqüències d'ADN; Subtipus PAM50; Genètica molecular Análisis de secuencias de ADN; Subtipo PAM50; Genética molecular DNA sequence analyses; PAM50 subtype; Molecular genetic Background: The SOLTI-1301 AGATA study aimed to assess the feasibility of a multi-institutional molecular screening program to better characterize the genomic landscape of advanced breast cancer (ABC) and to facilitate patient access to matched-targeted therapies in Spain. Methods: DNA sequencing of 74 cancer-related genes was performed using FFPE tumor samples in three different laboratories with three different gene panels. A multidisciplinary advisory board prospectively recommended potential targeted trea…

OncologyCancer ResearchDNA Alterationmedicine.medical_specialtymolecular targeted therapyAdvanced breast:Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES]Cancer therapy:terapéutica::farmacoterapia::terapia molecular selectiva [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]:Therapeutics::Drug Therapy::Molecular Targeted Therapy [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Breast cancerbreast cancerInternal medicineGene panelmolecular geneticmedicineDNA sequence analysesRC254-282Original ResearchFarmacologia molecular:neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES]:Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics [DISCIPLINES AND OCCUPATIONS]Molecular screeningbusiness.industryCancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseOncologyMama - Càncer - Tractament:disciplinas de las ciencias naturales::disciplinas de las ciencias biológicas::biología::biología computacional::genómica [DISCIPLINAS Y OCUPACIONES]Mama - Càncer - Aspectes molecularsPAM50 subtypebusiness
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